Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy
نویسندگان
چکیده
منابع مشابه
Cast nephropathy in multiple myeloma.
Case report A 54-year-old man presented with one-week history of bilateral loin pain, reduced urine output and malaise. Complete blood picture showed hemoglobin of 7.6g/dL (normal: 11.5-17g/dL) Serum biochemistry showed hypercalcemia and markedly impaired renal function with creatinine measuring 1081 µmol/L (normal: 80-120). Skeletal survey showed multiple osteolytic lesions, and bone marrow as...
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Cast nephropathy is the result of coprecipitation of immunoglobulin free light chains (FLCs) with Tamm-Horsfall glycoprotein (THP). It is a hallmark of multiple myeloma that has significant consequences. Treatment strategies in the past focused on reduction of serum FLC by control of the myeloma. In this issue, Ying et al. report on their successful synthesis of a cyclized competitor peptide th...
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myeloma cast nephropathy: Is there still a role for plasmapheresis? Luana Pillon, Raeshell S. Sweeting, Avi Arora, Alicia Notkin, Harold S. Ballard, Rosemary L. Wieczorek and Nelson Leung Department of Medicine, VA New York Harbor Health Care Systems, New York, New York, USA; Department of Medicine, New York University School of Medicine, New York, New York, USA; Division of Nephrology, Departm...
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A case of non-secretory multiple myeloma presenting as primary plasma cell leukaemia in a 65 year old woman is presented. Bone pain was the initial clinical manifestation. Laboratory analysis showed 20% of circulating immature plasma cells. Despite the presence of osteolytic lesions, no M-component could be demonstrated in serum protein electrophoresis, and serum and urine immunoelectrophoresis...
متن کاملNon-secretory multiple myeloma relapsing as extramedullary liver plasmacytomas.
We report a case of a 58-year-old woman with a true non secretory multiple myeloma of the producer type relapsing after many lines of therapy including the novel anti-myeloma drugs, which eventually relapsed as extramedullary liver plasmacytomas manifesting as a fatal acute cholestatic hepatitis. Due to the aggressiveness of this disease, new therapeutic modalities are necessary.
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ژورنال
عنوان ژورنال: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
سال: 2016
ISSN: 2249-782X
DOI: 10.7860/jcdr/2016/19060.7925